The article deals with the participation of the teaching staff and professors of Tomsk Imperial University in the organizing of medical aid to the wounded in the World War I. Moreover, they actively took part in the fulfillment of the defense orders for the battlefront, producing of medical drugs and development of asphyxiant gases countermeasures. The paper reconstructs the history of Tomsk University contribution to the struggle against Germany during the First World War on the basis of the existing scientific literature, documental materials, including the ones introduced into the research use for the first time and the periodical media. The article is devoted to those, who are interested in the history of the World War I and in the history of higher education and science in Russia, as well.